Never Combine These Over-the-counter Drugs

Painkillers and anti-anxiety medications. The metabolic pathways inside the body that are affected by opioid painkillers like hydrocodone (Oxycontin) are the same ones affected by benzodiazepines. Both classes of drugs depress certain bodily functions, mainly those that express pain and physical anxiety.

By taking both drugs at the same time, users put themselves at risk of serious illness, not the least of which includes heart failure.